Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages
نویسندگان
چکیده
منابع مشابه
Etymologia: Mycobacterium chelonae
Selective testing of dogs with exposure histories may yield misleading results with respect to local endemicity. Our fi ndings suggest that canine seroprevalence >5% can be a sensitive but nonspecifi c marker of increased risk for human Lyme disease. Because dogs do not transmit infection directly to humans (or humans to dogs), this association refl ects similar susceptibilities to tick-borne i...
متن کاملStudy of Organic Solvent Tolerance and Increased Antibiotic Resistance Properties in E. coli gyrA Mutants
Ciprofloxacin is one of the most widely used antibiotics for the treatment of several infections caused by Gram-negative bacteria, like E. coli. Changes in gyrA, encoding GyrA subunit of DNA gyrase, cause the resistance to ciprofloxacin. Some ciprofloxacin resistant gyrA mutants acquired constitutive expression of marRAB operon due to the gaining mutations in marR, a repressor of this operon...
متن کاملStudy of Organic Solvent Tolerance and Increased Antibiotic Resistance Properties in E. coli gyrA Mutants
Ciprofloxacin is one of the most widely used antibiotics for the treatment of several infections caused by Gram-negative bacteria, like E. coli. Changes in gyrA, encoding GyrA subunit of DNA gyrase, cause the resistance to ciprofloxacin. Some ciprofloxacin resistant gyrA mutants acquired constitutive expression of marRAB operon due to the gaining mutations in marR, a repressor of this operon...
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The type of cutaneous infection varies mainly according to the patient's immune status, and the disseminated form is mostly found in the context of immunosuppression. We report the case of a 62-year-old male who was under long-term systemic corticosteroid therapy and presented with a 7-month history of multiple painless cutaneous lesions at various stages of development: papules, nodules, pustu...
متن کاملThe mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance.
Intrinsic drug resistance in Mycobacterium tuberculosis limits therapeutic options for treating tuberculosis. The mycobacterial transcriptional regulator whiB7 contributes to intrinsic resistance by activating its own expression and many drug resistance genes in response to antibiotics. To investigate whiB7 activation, we constructed a GFP reporter to monitor its expression, and we used it to i...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2021
ISSN: 1471-2180
DOI: 10.1186/s12866-021-02224-z